Tadalafil Basic Info
Trade Name: Cialis, Adcirca
Protein Binding: 94%
Biological Half-life: 17.5 hours
CAS Number: 171596-29-5
Molar Mass: 389.404 g/mol
Uses: Sex Enhancement
Suitable for: Adult
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What is Tadalafil?
Tadalafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). It is in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis.
What are the uses of Tadalafil?
Penile erection occurs when the penis fills with blood. This happens because the blood vessels that bring blood flow to the penis dilate, thus increasing the blood supply. At the same time, the blood vessels that remove blood from the penis contract. As a result, blood accumulates, causing an erection. When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP, which controls the dilation and contraction of the blood vessels that carry blood to and from the penis. Another substance, PDE5, destroys cGMP. When this occurs the blood vessels return to their normal size and the erection ends. Tadalafil stops PDE5 from destroying cGMP. This causes the erection to last for longer.
How does Tadalafil work?
PDE5 is a substance produced in the lungs and other parts of the body that breaks down another substance called cyclic guanosine monophosphate (GMP). Cyclic GMP causes the blood vessels (arteries) to relax and widen. Tadalafil decreases the activity of PDE5, so that more cyclic GMP is available for the blood vessels inside the lungs. This leads to relaxation, or widening, of those vessels. Relaxing and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function. This reduces blood pressure in the lungs which generally results in the ability to be more active. Research studies have verified this improvement.
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Tadalafil For Sex Enhancement