Anastrozole is approved to treat breast cancer in postmenopausal women who have any of the following types of breast cancer–
Early-stage, hormone receptor positive (HR+) breast cancer. It is used in women who have already received other treatment.
Locally advanced or metastatic breast cancer that is HR+ or hormone receptor unknown (it is not known whether it is HR+ or hormone receptor negative). It is used as first-line therapy in these patients.
Advanced breast cancer that has gotten worse after treatment with tamoxifen citrate.
Anastrozole is also being studied in the treatment of other conditions and types of cancer.
Definition from the NCI Drug Dictionary – Detailed scientific definition and other names for this drug.
MedlinePlus Information on Anastrozole – A lay language summary of important information about this drug that may include the following:
warnings about this drug,
what this drug is used for and how it is used,
what you should tell your doctor before using this drug,
what you should know about this drug before using it,
other drugs that may interact with this drug, and
possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Find Clinical Trials for Anastrozole – Check for trials from NCI’s list of cancer clinical trials now accepting patients.
People who have an average waistline remain unsatisfied and strive to look like the fitness models/bodybuilders in magazine and on their their Facebook newsfeeds.
Unfortunately, losing weight is often a slow and tedious process. Counting calories, weighing yourself everyday and cutting out junk foods.
As a result, many men and women decide to take cutting steroids.
Cutting steroids are a faster and less-tedious way of burning fat. Simply pop a few pills and your body starts to melt the fat away…
So, which are the best steroids for weight loss?
When it comes to purely fat burning and getting lean; clen is probably the best steroid there is. It has powerful thermogenic effects, turocharging your metabolism and BMR. In short, clen will make your body burn a tonne of calories at rest, making it extremely easy to undereat and burn fat.
Because clen increases adrenaline output, you’ll also become more alert and energized when taking this cutting steroid. In terms of side effects, you won’t notice much from clen. Some users may experience occasional insomnia, due to the stimulating effects of this compound. Other than that, as steroids go, clen is very safe and widely used.
Anavar, or Oxandrolone, is another potent fat burner. Anavar is slightly different to clen, because it won’t just help you burn a significant amount of fat; but you’ll also become a lot stronger in the gym and may even add some lean muscle mass in the process.
Anavar is also a very safe steroid to take in oral form, with many users noticing zero side effects. This is why some anavar manufacturers are able to charge a high price, because it’s in such high demand (thanks to lots of average Joe’s using this steroid and not just bodybuilders).
You won’t just burn fat when on anavar, but you’ll also lose water weight; lowering the number on the scales even more. Losing water basically means that you’ll look even slimmer during a cycle, as the more water your body holds; the more puffy/bloated you can appear.
So, in terms of weight loss – the less water the better!
Winstrol produces similar results to anavar, as it’s one of the best steroids for fat loss. However, the main difference is that winstrol is a more powerful steroid when it comes to building muscle.
So, if it’s in your interest to build some muscle whilst burning fat; winstrol is the better steroid to take.
Winstrol is ideal for those who are wary about losing muscle when losing weight, and don’t want to look too skinny after hard dieting.
Winstrol will also help you eliminate water from the body, helping you look more toned during a cycle. You can lose as much as 5lbs of water weight within the first 48 hours on winstrol. And if you stack winstrol with anavar, you can experience even more water loss.
Out of all of the cutting steroids mentioned so far, testosterone is the best when it comes to building lean muscle.
In fact, testosterone is so anabolic, it can be used during a bulking cycle to help bodybuilders gain huge amounts of muscle. However, if you’re dieting you won’t experience big muscle gains, as you’ll be on lower calories.
Instead by adding testosterone to your weight loss stack; you’ll preserve your muscle and if you’re lucky you might add 5-10lbs – when combined with regular weight lifting.
Best Steroid Stack for Weight Loss
If you’re a woman, I don’t recommend taking testosterone if your goal is to lose weight because it can cause you to look and sound more manly.
…It’s definitely not worth losing your femininity, in return for losing your love handles.
However, clenbuterol and anavar are 2 very powerful weight loss steroids that will help women lose fat fast; without causing you to develop any manly features.
Taking any of the compounds listed in this article will give you good results (assuming you don’t go on a massive junk food binge!). Another option is to stack all 4 steroids together, which’ll help you burn fat a lot faster.
Trenbolone Acetate is an extremely powerful anabolic steroid and is considered the single greatest anabolic steroid by many performance enhancing athletes. This is one of the most versatile anabolic steroids on the market and can provide benefits quite unlike any other steroid. Trenbolone Acetate is also subject to numerous myths in the anabolic steroid world, but hopefully we’ll be able to dispel these myths and gain a firm understanding of the compound.
Trenbolone Acetate is officially classified as a veterinarian grade anabolic androgenic steroid. The Trenbolone hormone itself was first created in the late 1960’s and the Acetate version would be sold under the names Finajet and Finaject. However, this is not the only Trenbolone compound. The same hormone would appear on the pharmaceutical market under the name Parabolan and was manufactured by Negma Laboratories out of France. This version of Trenbolone was comprised of the same active hormone that makes up Finajet and Finaject with the ester attached being the only exception. Parabolan carries the much larger Hexahydrobenzylcarbonate ester. It would also be the only Tren hormone ever manufactured for human use and would be discontinued in 1997 despite a lot of therapeutic success. See the Parabolan profile for more information.
Hoechst-Roussel, the manufacturer of the original Trenbolone Acetate products, would discontinue its veterinarian line in the late 1980’s. However, during this time they would introduce Finaplix pellets; small subcutaneous implant pellets that contain the active Trenbolone Acetate compound. The pellets were intended to be used in cattle in order to increase the lean tissue of the animal shortly before slaughter. The pellets were so successful they have become a regular and integral part of the livestock market ever since. Numerous performance enhancing athletes have also purchased Finaplix pellets in order to convert them into their own injectable Trenbolone Acetate compound.
While converted Finaplix pellets are common in many enhancement circles, over the years most underground labs have also begun to carry their own line of injectable Trenbolone Acetate. Other than testosterone compounds, it is perhaps the most sought after injectable steroid on the market. The benefits this steroid can provide to a cutting cycle are unmatched. In fact, you could stack numerous other anabolic steroids together and still not reach the level of power in Trenbolone Acetate. It is also one of the best off-season bulking steroids available. Not only will it pack on a lot of mass and cause tremendous gains in strength, it will do so in a cleaner way than most traditional bulking steroids. While it is not the only Tren form available, Trenbolone Acetate is preferred by most athletes. It is much easier to maintain peaked and stable blood levels with this version, and when coupled with the benefits it is not too hard to see why many refer to Trenbolone Acetate as the king of kings.
In a chemical sense, Trenbolone Acetate is a slightly modified version of nandrolone, the parent molecule in Deca Durabolin. As such, you can expect many of the same actions. However, Tren Acetate carries a couple of modifications that make it incredibly popular. First, this product does not aromatize, or convert to estrogen in the bloodstream. This is great news for those who are particularly sensitive to the androgenic effects of steroids. Second, it carries a short ester which means it begins working soon after use. It has an active half-life of just under three days, so every-other-day dosing is best.
Tren Acetate behaves like many other anabolic steroids. It enhances your body’s ability to synthesize protein and it helps your muscle tissue retain more nitrogen. When your body is able to create proteins more quickly, and when the building blocks for those proteins (namely nitrogen) are available in abundance, you can experience muscle growth on an epic scale. Aside from this, Trenbolone Acetate will also work to promote insulin-like growth factor, which is responsible for repairing and rejuvenating tissues throughout your body. It also increases red blood count significantly; with more red blood cells, you can better oxygenate your muscles and provide them a prime environment for growth.
Trenbolone Acetate has a place in both bulking and cutting cycles. Not only does it put the body in a prime anabolic state for muscle growth, but it also inhibits glucocorticoid hormones, which are responsible for creating fat deposits in the arms, thighs, and abdominal areas. In a bulking cycle, Tren primes the body by putting it in an anabolic state. While cutting, Tren helps you hold on to gains as you cut calories and increase the intensity of your workouts. It is all about your diet and exercise plan, as well as your dose.
The average Trenbolone Acetate dose varies based on your cycle and stack. During an off-season bulking cycle, most bodybuilders find that 50mg every other day is comfortable and effective. Some men tolerate up to 100mg every other day with no issues, and they find that this does offers the best results for them. During a cutting cycle, people tend to push the envelope a little more with Tren and utilize doses even higher than 100mg every other day, but not everyone can tolerate these as the risk of side effects increases. No one should ever use more than 200mg every other day, even if they seem to tolerate it well.
Trenbolone acetate is one of the most popular, most powerful, and most loved anabolic steroids available to mankind. It fits well in almost any cycle or stack, and its results are incomparable. However, it is important to note that Tren is not for beginners; you should only use it if you have a good deal of experience with cycling anabolic steroids.
Although most people probably think of buff celebs like Sylvester Stallone or Arnold Schwarzenegger when they think of anabolic steroids, these compounds are capable of much, much more. In fact, when you use the right steroid at the right dose, it is possible to actually lose weight in the form of body fat without losing your muscle composition.
When to consider steroids to lose weight?
Before you consider using anabolic steroids (or any other compound, for that matter) to burn fat or lose weight, you should first consider your body type. Remember that the compounds athletes and bodybuilders use to shed body fat have very specific indications. If you are overweight and you want to get fit, then anabolic steroids are not for you. You should reduce your body fat naturally with diet and exercise before you consider utilizing any performance enhancement substance. Excess body fat puts undue pressure on your heart and organs, and adding steroids to the mix can make things worse.
Anabolic steroids for cutting
Anabolic steroids are not generally viewed as weight loss supplements, but there are some that can certainly help you lose body fat. These includeWinstrol, Trenbolone, and Anavar, but you must dose them carefully in order to reap the weight loss benefits. You will not experience rapid weight loss with these for the most part, but they can help you melt away the last remaining extra body fat to give your muscles a more ripped and toned look. Many athletes use these compounds a few weeks before competitions to boost their overall aesthetic appeal, to make their muscles “pop”, and to bring veins to the surface of the skin. Trenbolone is the number one choice among experienced steroid users.
Why trenbolone is so effective
Before you can understand why Trenbolone works the way it does, you first need to understand that you have two types of fat, or adipose tissue, in your body. First, you have visceral adipose tissue, which surrounds your organs and has very little effect on your overall appearance. Second, you have subcutaneous adipose tissue, which rests just below the skin and has a tremendous impact on your appearance. As Trenbolone binds to androgen receptors (which it does very well), it inhibits lipid uptake. This means that your body cannot continue to add to its subcutaneous fat stores. As such, when you work out, you burn away the subcutaneous adipose tissue and obtain the “cut” appearance.
Something even better
Now, if you want to truly burn away body fat but you are not interested in using an anabolic steroid to do so, then you might want to consider using Clenbuterol, instead. This is a bronchodilator that has stimulant and thermogenic effects. Not only will it give you energy, but it will also increase your body temperature, which in turn helps improve your body’s overall metabolism. With the right doses over the right periods of time, it is possible to lose between eight and 10 pounds of pure body fat in a single cycle.
Neither anabolic steroids nor compounds like Clenbuterol can work miracles, but they are go-to options for athletes and bodybuilders who want to reduce their body fat and obtain the sculpted appearance they desire. Either is completely safe when used responsibly, too.
Many steroids do have some adverse side effects. Trenbolone is one of the harsher steroids because of its powerful anabolic and androgenic properties.
Individual responses and sensitivity to Tren can play a role in the severity of the side effects, if any at all.
Some individuals have one injection and they are knocked out and others have been cycling Tren for years and have no health issues what so ever.
Research has indicated the following side effects associated with high doses of Trenbolone:
Increased hair loss
Increased bouts of acne
Loss of sex drive
Increased anxiety levels
A quick resting heart rate
Trenbolone is not a catalyst for oestrogen conversion and therefore is not associated with bloating and water retention.
Nevertheless, Tren is a potent progestin and this can lead to gynecomastia, especially in people who already susceptible to this condition.
In addition, Tren can also cause suppression of testosterone levels, it will close down your natural production of testosterone and can shrink your testicles.
Trenbolone also seems to give users a poor sleep pattern and insomnia. Plus it can cause severe sweating during the night and even the simplest activities such as walking upstairs can cause you to sweat a lot more than usual.
Tren usage can also impair cardiovascular function which can also have a negative impact on daily functional fitness. Therefore, daily activities such as walking, lifting and carrying etc; can become a lot more arduous.
There is evidence to suggest that Tren usage can increase your blood pressure levels and this can place additional stress/strain on the heart.
In terms of the kidneys, long-term Tren usage can cause your urine to be an orange-brown colour. This discolouration of the urine has been associated with Tren’s ability to increase your sweat rate and water loss from excessive body heat.
While using Tren it is important to keep an eye on your hydration levels.
The degree to which testosteronelevels decline varies between men, but an increasing number of men are experiencing the effects of reduced testosterone levels as more men now live beyond the age of 60.
One study investigated the effects of testosterone supplementation (80 milligrams a day) in older men who had low to normal testosterone levels. Specifically, they looked at testosterone’s potential effects on:
Bone mineral density
Quality of life
They also assessed the safety of testosterone supplementation, finding no adverse effects of twice-daily doses. The researchers observed no beneficial effects of supplementation on functional mobility, bone mineral density, or cognitive function. They did, however, observe some effects on body composition and metabolic risk factors.
Compared with placebo, testosterone resulted in:
Lean body mass increase
Fat mass decrease
In spite of fairly limited evidence to support its health benefits, the prescription of testosterone for older men has increased dramatically in recent years; an increase of 170 percent was seen over the 5 years to 2012.
Specialists in testosterone research and reproductive health say that until there is stronger evidence of its benefits and safety, testosterone treatment in elderly men should be restricted to those with clinical symptoms of demonstrably low testosterone.
One recent study of testosterone found that its effects varied widely between different men.
The 2013 study found that lean mass, muscle size, and strength were regulated by male hormones while fat accumulation was primarily a consequence of estrogen deficiency. Meanwhile, sexual function was regulated by both androgens and estrogens.
In summary, additional research into testosterone replacement is needed for physicians to be better able to understand its potential risks and benefits and which individuals may benefit most.
The effects of Methyltestosterone are brought on by simply increasing the amount of circulating androgens through exogenous use of this hormone. This could be done to combat a condition brought on by low levels, or it could be to enhance androgen levels above baseline levels to help combat another condition. However, while both are possible the former is the most common in a medical setting. By supplementing with this androgen, the effects of Methyltestosterone should enhance the individual’s sex drive and boost energy levels that are often in decline with low levels of the hormone in the body. This is where the effects of Methyltestosterone will benefit the menopause or andropause patient greatly. Such conditions will also be the most common point of use for this particular version of the testosterone hormone.
For the purpose of performance enhancement, the effects of Methyltestosterone will normally be found lacking. For a true performance boost it would require long term high dose use and due to this steroid’s hepatotoxicity it simply isn’t a viable option. We will, however, find the steroid is nowhere near as toxic as many have inaccurately believed, but it still won’t be viable for long term performance use.
Where the effects of Methyltestosterone could primarily benefit the athlete will be in a pure androgenic sense, not anabolic. By supplementing for short periods of time with a significant dose, the high level of androgenic activity could increase aggression significantly. This could be beneficial to power lifters and other strength athletes prior to competition. However, when looking at the effects of Methyltestosterone in this regard there is something we need to clear up. There is no anabolic steroid that can alter an individual’s personality or take away his ability to distinguish from right or wrong. A non-violent person cannot turn into a violent animal due to any anabolic steroiduse. With most anabolic steroids, the aggression factor will not be a factor at all, but with this particular androgen, as is with the steroid Halotestin an enhanced aggressive nature is possible. It’s also important to note that aggression in of itself is not a bad thing. What we do with aggression is what makes it right or wrong. Enhanced aggression can be extremely beneficial when it’s used for the right purpose, such as competitions that surround strength. Some bodybuilders may also find the effects of Methyltestosterone beneficial in this regard right before competition to help them through the final stages when energy levels are often low. However, due to the potent estrogenic activity of Methyltestosterone there are normally better options.
An important note on the effects of Methyltestosterone as it pertains to aggression – if you are already a violent individual this is a steroid you should avoid. If you are a violent individual the enhanced aggression will only make you more aggressively violent. If you are a sane individual, the effects of Methyltestosterone will not change this in any way and you should still display your same level of self control.
What are some important considerations when your steroids’ dosage changes?
As the control of your disease improves, or if serious side effects develop, your healthcare provider may decrease your steroiddose by tapering the dose to prevent “breakthrough” symptoms and to allow the adrenal glands time to function again. If you have been taking steroids long-term do not stop your steroids abruptly. Follow your healthcare provider’s recommendations.
As your body adjusts to a lower steroid dose, you may notice some withdrawal side effects. These may include an increase in breathing difficulty due to worsening of your disease, fatigue, weakness, depression and muscle and joint pain. If breathing difficulty occurs, or if any of the above symptoms are severe, notify your healthcare provider. The non-respiratory side effects usually disappear within a few weeks or months.
If your steroid dose has recently been decreased or stopped and you have a serious illness, surgery or injury, you may require a short steroid burst. During this time, your adrenal glands may not be functioning at full capacity and cannot handle stress to the body. This is important if you have taken routine steroid pills within the last year or completed a burst within the past two weeks. Inform all of your healthcare providers that you have been on steroid treatment.
Some people do not react normally to steroid medicine. Special testing may be required and the medicine dose may need to be adjusted.
Frequently people have concerns about taking corticosteroid (“steroid”) medicine. Please discuss concerns that you have about steroid use with your healthcare provider. Discuss all medicines and herbal supplements with your healthcare provider to make sure they don’t interact with the steroids you take. It is important to follow your healthcare provider’s directions when taking steroids.
Trenbolone is one of the most powerful anabolic steroids available . It is injected intramuscularly into one of the several injection sites on the body. Trenbolone is not available in a form that can be taken orally. It is an intermediate to advanced level steroid and it should never be used by people who have recently started using anabolic steroids. First time users or those who are about to start their first anabolic steroid cycle should not take trenbolone. Only those who have already completed several cycles of testosterone or any other beginner level anabolic steroid may use trenbolone.
You should give trenbolone its due respect because it is associated with certain side effects that are not seen with the use of other anabolic steroids. If you use it irresponsibly or
without knowing what it can do, it can cause serious health effects.
Trenbolone can be obtained in three esterified variants – Trenbolone Acetate, Trenbolone Enanthate, and Trenbolone Cyclohexylmethylcarbonate also known as Parabolan. The basic difference between these three variants is their half lives.
Advantages of trenbolone
Trenbolone is a strong androgenic compound. This compound along with its fat burning property gives it many advantages. It is basically derived from the anabolic steroid nandrolone, but unlike nandrolone it has no estrogenic property. It cannot be converted into estrogen because it has a double bond on the c9-10 carbon. This makes it totally resistant to the action of aromatase, which converts steroids without this bond into estrogen. So trenbolone is a flexible and versatile anabolic steroid, which provides tremendous muscle gain.
Trenbolone affects muscle growth in many ways. It increases the level of IGF-1 (Insulin like growth factor) inside the muscle tissue. On the other hand, muscle satellite cells, the cells that repair the damage to muscle fibers also become more sensitive to IGF-1 and related growth factors. It also increases the DNA level in the muscle cells significantly.
Trenbolone is strongly attracted to androgen receptors. In fact, in trenbolone this property is stronger than that of testosterone. Much like how the Celsius scale uses the freezing point and boiling point of water to measure temperature, testosterone is used as a baseline to measure the potency of anabolic steroids. For example, while the androgenic and anabolic property of testosterone is 100 each, the androgenic and anabolic property of trenbolone is 500 each. This means trenbolone is five times stronger in its androgenic and anabolic properties when compared to testosterone. To be benefited from 1000 mg of testosterone, only 200 mg of trenbolone has to be administered. This means you do not need to take large doses to see the effects. In fact, large doses can lead to adverse affects.
Like nearly all other anabolic steroids, nitrogen retention also increases in muscle fibers after taking trenbolone. The drug also has anti-catabolic properties. Trenbolone can prevent catabolism or breakdown of muscle that usually accompanies intense exercise . Cortisol and its related hormones have receptor sites inside muscle cells. Cortisol is responsible for breaking down protein for fuel. It also suppresses inflammation that develops when the tissue is injured. It actually binds with these receptors, inhibiting the action of cortisol and other glucocorticoid hormones.